Innovative Enhancements

To ensure you have the best possible chance of a healthy pregnancy while in our care, we have expertise in providing services based on innovative technologies with leading evidence of maximizing outcomes.

Preimplantation Genetic Testing for Aneuploidy (PGT-A) or for Monogenic disorders (PGT-M) refers to procedures where embryos obtained through an IVF cycle are evaluated for genetic disorders prior to implantation.

PGT-A (formerly known as PGS, Preimplantation Genetic Screening) is used to identify embryos that may be affected by chromosomal abnormalities. PGT-A increases your chances of pregnancy and delivering a healthy baby per embryo transfer while it decreases your likelihood to miscarry. PGT-A also enables confident single embryo transfer, avoiding health complications associated with twin or triplet pregnancies. An additional benefit of PGT-A is that it can reduce the number of embryo transfers you require to achieve pregnancy, potentially reducing the time and costs of extra cycles.

PGT-M (formerly known as PGD, Preimplantation Genetic Diagnosis) is used to help prevent certain diseases or disorders from being passed on to the child from the parent (inherited genetic disorders). In most cases for PGT-M, the parent(s) from which the egg or sperm is provided have been genetically screened and identified to be carriers of potential genetic disorders.

By analyzing DNA from each embryo, unaffected embryos can be preferentially selected for transfer. This test is indicated for those at risk of passing on a single gene disorder such as cystic fibrosis, fragile X syndrome, muscular dystrophy, Huntington disease, and many others.

Preimplantation Genetic Testing

(PGT-A & PGT-M)

ERA (Endometrial Receptivity Analysis)

ERA is an innovative test that helps pinpoint the exact time when your endometrium is receptive to embryo implanting. This test may help improve chances of pregnancy for those with repeated failed IVF.

ERA involves taking a small sample (biopsy) of endometrial cells at a particular times in your cycle. Cells in the endometrium produce certain types ⁠of genetic material during the window of implantation (WOI).⁠ An ERA can identify when endometrial cells ⁠are “Receptive” or “Nonreceptive”. ⁠We can then time your embryo ⁠transfer to the most optimal time to maximize chance of achieving pregnancy.

EndomeTRIO (ERA, EMMA, ALICE)

EndomeTRIO is a series of tests including ERA - described in the section above - and two additional tests: ALICE and EMMA.

ALICE: Analysis of Infectious Chronic Endometriosis

ALICE detects chronic endometritis-causing bacteria and recommends appropriate antibiotics. Endometritis is a condition affecting 30% of infertile patients that is linked to implantation failure and recurrent miscarriages.

EMMA: Endometrial Microbiome Metagenomic Analysis

EMMA provides information on the proportions of healthy endometrial bacteria, including those linked to higher pregnancy rates. It will recommend antibiotic and probiotic treatment, if needed, to restore an optimal microbiome. This is done in conjunction with ALICE.

Endometrial Biopsy

(ERA & EndomeTRIO)

Endometrial Image Assessment

This innovation is non-invasive and uses ultrasound technology to assess the receptivity of your endometrial lining to embryo transfer in order to increase the probability of successful implantation.

In cases where receptivity is high, we can be more confident in proceeding with transferring the embryo. In cases where we assess receptivity to be low, the best decision may be to cryopreserve the embryo for transfer in a future cycle.

Embryo Assisted Hatching

Assisted hatching may be helpful for IVF patients who are older (more than 37 years old) or who have had a prior IVF failure. It is a procedure where we can help the embryo “hatch” from its “shell” by creating a small crack in its outer layer of cells (zona pellucida). There is a body of evidence indicating that assisted hatching can help an embryo implant in the uterus, leading to higher pregnancy rates in some patients.

Assisted hatching can also be done on previously frozen and thawed embryos.

Sperm Selection

(ZyMōt Sperm Separation)

This technique separates the healthiest, highest-performing sperm to increase the likelihoods of success for treatments such as IUI and IVF.

ZyMōt is used to separate the sperm with better DNA integrity from the sperm with more fragmented DNA.

Have Questions?

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Learn About Innovative Enhancements

Our experts have shared helpful insights on current innovations that enhance the outcomes of fertility treatments. Check out the following quick reads to learn more.

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